Immunoglobulin kappa locus, also known as IGK@, is a region on human chromosome 2 that contains genes for the kappa (κ) light chains of antibodies (or immunoglobulins). In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this …
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Association between the Igk and Igh immunoglobulin loci mediated by the 3¢ Igk enhancer induces ‘decontraction’ of the Igh locus in pre–B cells
The human IGK locus is located on chromosome 2 on the short arm, at band 2p12. The orientation of the locus has been determined by the analysis of translocations, involving the IGK locus, in leukemia and lymphoma.
During B lymphopoiesis, recombination of the locus encoding the immunoglobulin κ-chain complex (Igk) requires expression of the precursor to the B cell antigen ...
Here we demonstrate that STAT5 bound as a tetramer to E κi and enabled recruitment of the histone methyltransferase Ezh2 that decorated E κi, ... Igk locus (above ...
DNA Overview. The human IGK locus is located on the chromosome 2, on the short arm, at band 2p11.2 . The list of human IGK genes is available at IMGT/GENE-DB.
Human (Homo sapiens) IGK locus on chromosome 2 (2p11.2) The orientation of the human IGK locus on the chromosome is reverse (REV). Legend: Colors are according to ...
Complete information for IGK gene (Protein Coding), Immunoglobulin Kappa Locus, including: function, proteins, disorders, pathways, orthologs, and expression.
IGK immunoglobulin kappa locus. Also known as: IGK@
During B lymphopoiesis, recombination of the locus encoding the immunoglobulin κ-chain complex (Igk) requires expression of the precursor to the B cell antigen ...
Complete information for IGK gene (Protein Coding), Immunoglobulin Kappa Locus, including: function, proteins, disorders, pathways, orthologs, and expression.
TY - JOUR. T1 - Topological organization of the MYC/IGK locus in Burkitt's lymphoma cells assessed by nuclear halo preparations. AU - Rätsch,A.
Article: Nature Immunology 6, 198 - 203 (2004) Published online: 26 December 2004; | doi:10.1038/ni1154 Epigenetic ontogeny of the Igk locus during B cell development
Epigenetic ontogeny of the Igk locus during B cell development Maya Goldmit1,4, Yanhong Ji1,4, Jane Skok2,4, Esther Roldan2, Steffen Jung3, Howard Cedar1&
FIGURE 1. Schematic overview of classical rearrangements in the human IGK locus. IGK recombination mostly starts with a Vκ-Jκ rearrangement.
HGNC approved symbol report for the gene IGK (HGNC_ID:5715)
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IMGT Locus in Focus Exp Clin Immunogenet 2001;18:161–174 Nomenclature of the Human Immunoglobulin Kappa (IGK) Genes Marie-Paule Lefranc IMGT Nomenclature …
The LDI PCR method developed here should also be useful for the analysis of chromosomal translocations affecting the IGK locus in general. Related: ...
Analysis of Expressed and Non-Expressed IGK Locus Rearrangements in Chronic Lymphocytic Leukemia ... The IGK locus permits extensive editing because direct V-to-J
Jane Skok, PhD. Associate Professor of ... the Igk locus interacts with the Igh locus to co-ordinate the transition from Igh to Igk rearrangement and thus from one ...
Association between the Igk and Igh immunoglobulin loci mediated by the 3′ Igk enhancer induces 'decontraction' of the Igh locus in pre-B cells