Immunoglobulin kappa locus, also known as IGK@, is a region on human chromosome 2 that contains genes for the kappa (κ) light chains of antibodies (or immunoglobulins). In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this region.
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IGK immunoglobulin kappa locus. Also known as: IGK@
The human IGK locus at 2p12 spans 1820 kb. It consists of 76 IGKV genes belonging to 7 subgroups, 5 IGKJ segments, and a unique IGKC gene The 76 IGKV genes are organized in two clusters separated by 800 kb.
Complete information for IGK gene (Protein Coding), Immunoglobulin Kappa Locus, including: function, proteins, disorders, pathways, orthologs, and expression.
Human (Homo sapiens) IGK locus on chromosome 2 (2p11.2) The orientation of the human (Homo sapiens) IGK locus on the chromosome 2 (2p11.2) is reverse (REV).
Association between the Igk and Igh immunoglobulin loci mediated by the 3¢ Igk enhancer induces ‘decontraction’ of the Igh locus in pre–B cells
Article: Nature Immunology 6, 198 - 203 (2004) Published online: 26 December 2004; | doi:10.1038/ni1154 Epigenetic ontogeny of the Igk locus during B cell development
TY - JOUR. T1 - Topological organization of the MYC/IGK locus in Burkitt's lymphoma cells assessed by nuclear halo preparations. AU - Rätsch,A.
IMGT Repertoire (IG and TR) Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 1. Locus and genes 1. ... IGK: Human, Mouse, Rabbit ...
IMGT Repertoire (IG and TR) Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 1. Locus and genes 1. ... IGK: Human, Mouse, Rabbit ...
The human IGK locus is probably the most complex of all antigen-receptor loci because of the presence of many elements that can be involved in V(D)J recombination.
title = "Topological organization of the MYC/IGK locus in Burkitt's lymphoma cells assessed by nuclear halo preparations", abstract = "In Burkitt's lymphoma (BL) cells characteristic chromosomal translocations juxtapose the MYC oncogene to one of the three immunoglobulin (IG) gene loci.
During B lymphopoiesis, recombination of the locus encoding the immunoglobulin κ-chain complex (Igk) requires expression of the precursor to the B cell antigen ...
Epigenetic ontogeny of the Igk locus during B cell development Maya Goldmit1,4, Yanhong Ji1,4, Jane Skok2,4, Esther Roldan2, Steffen Jung3, Howard Cedar1&
IGK Cancer Genome Anatomy ... The LDI PCR method developed here should also be useful for the analysis of chromosomal translocations affecting the IGK locus in ...
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IGK locus. The human IGK locus at 2p12 spans 1820 kb. It consists of 76 IGKV genes belonging to 7 subgroups, 5 IGKJ genes, and a unique IGKC gene.
Unraveling the Consecutive Recombination Events in the Human IGK Locus1 ... configuration of the IGK locus was determined using BglII and BamHI/
IGK@ topic. Immunoglobulin kappa locus , also known as IGK@ , is a region on human chromosome 2 that contains genes for the kappa (κ) light chains of antibodies (or immunoglobulins). In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this region.
Molecular characterization of a t(2;7) translocation linking CDK6 to the IGK locus in CD5 − monoclonal B-cell lymphocytosis
Apr 30, 2014 · IGK@ topic. Immunoglobulin kappa locus , also known as IGK@ , is a region on human chromosome 2 that contains genes for the kappa (κ) light chains of antibodies (or immunoglobulins). In humans the κ chain is coded for by V (variable), J (joining) and C (constant) genes in this region.
FIGURE 1. Schematic overview of classical rearrangements in the human IGK locus. IGK recombination mostly starts with a Vκ-Jκ rearrangement.
Histone reader BRWD1 targets and restricts recombination to the Igk locus. Malay Mandal 1, Keith M Hamel 1, Mark Maienschein-Cline 2, ... For the Igk locus, ...